Fibroadipogenic Progenitors

Role of fibroadipogenic progenitors in muscle fatty degeneration

Fatty infiltration, or the deposition of fat tissue within skeletal muscle, is a major clinical burden that   contributes to the pathological progression of many muscle pathologies, such as muscular dystrophies and muscle wasting due to aging or disuse. It is also linked to poor metabolic outcomes such as insulin resistance. Unfortunately, no treatment currently exists for fatty infiltration mainly because we still lack knowledge regarding the origin, the molecular mechanism, and the pathological progression of fatty infiltration.
At the Laboratory of Exercise and Health we aim to use cutting edge technology, such as single cell RNA sequencing, to gain a more complete understanding of the molecular mechanisms underlying fatty infiltration in both animal models and human patients.